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And without high-quality trials, experts don’t know how much is best for a given purpose. The staff at Roth’s dispensary told her, “Try some once or twice a day and see what happens.” (Half a dropper’s worth was a good amount for her.) One thing scientists feel confident about is that CBD is not dangerous. It won’t damage vital organs even at doses as high as 5,000 mg a day, Marcu says, and nobody has died from simply overdosing on a cannabis product.
Along with its better-known counterpart, THC (delta-9-tetrahydrocannabinol, the chemical that produces the marijuana high), CBD is one of more than 400 compounds found in the oils of cannabis plant species, which include marijuana and hemp. Unlike THC, CBD will not make you high. That said, this doesn’t mean CBD is not at all psychoactive, as many assert, says Jahan Marcu, Ph.D., director of experimental pharmacology and behavior at the International Research Center on Cannabis and Mental Health in New York City: “CBD does change cognition. It affects mood, which is why people take it for anxiety. And some find that it makes them more alert.”
En un estudio in vitro sobre el efecto de CBD en la muerte celular programada de líneas celulares de cáncer de mama, se encontró que CBD indujo la muerte celular programada, independientemente de los receptores CB1, CB2 o los receptores vaniloides. El CBD inhibió la supervivencia tanto de las líneas celulares de cáncer de mama con receptor de estrógeno positivo como aquellas con receptor de estrógeno negativo mediante la inhibición de la apoptosis, de modo dependiente de la concentración y, al mismo tiempo, con poco efecto en las células mamarias no oncógenas. También se observó en otros estudios el efecto antitumoral de los canabinoides (es decir, CBD y THC) en modelos preclínicos de cáncer de mama.[19,20]
Our bodies are thought to produce endocannabinoids by the billions every day. “We always thought the ‘runner’s high’ was due to the release of dopamine and endorphins. But now we know the euphoria is also from an endocannabinoid called anandamide,” its name derived from the Sanskrit word for bliss, says Joseph Maroon, M.D., clinical professor and vice chairman of neurosurgery at the University of Pittsburgh Medical Center. We produce these natural chemicals all day, but they fade quickly because enzymes pop up to destroy them. That’s where CBD comes in: By blocking these enzymes, CBD allows the beneficial compounds to linger. This is why Amanda Oliver, 31, a career consultant in Charleston, SC, pops a CBD gummy bear each night before bed. “I used to lie there tossing and turning as my mind raced from work projects to whether I had set the home alarm,” Oliver says. One piece of candy with 15 mg of CBD is enough to shut off her brain and facilitate sleep. She also swears by the CBD oil she takes at the height of her period, which she says quells her debilitating cramps.
Soy farmacéutica y regento la Farmacia Meritxell, que está en Andorra. Desde el principio he querido dar un nuevo enfoque y concepto a mi farmacia, nos hemos especializado en el fármaco internacional lo que me ha llevado a ser un punto de referencia y reconocimiento en el ámbito sanitario y, también, a conocer productos relacionados con la salud excepcionales de muchas partes de todo el mundo. Además, me ha dado la oportunidad de colaborar con los mejores especialistas y clínica, ampliando mi experiencia. En 1999, creamos la primera página web en español relacionada con el mundo farmacéutico y sanitario, www.farmaciameritxell.com