La unión de un ligando cannabinoide a su receptor conlleva la activación de una proteína G citoplasmática que mayoritariamente es inhibitoria y por ello denominada Gi. Esta unión conlleva la inhibición de la actividad de la adenilato ciclasa, una enzima excitatoria implicada en diversos procesos metabólicos. Mecanismos adicionales incluyen la inactivación de canales iónicos y otros sistemas enzimáticos.
Sublingual CBD Oils – also known as CBD Tinctures or CBD Hemp Oil – are the most popular type of CBD products, because of their high bioavailability and rapid absorption. There are many other kinds of products as well, including CBD edibles, CBD topicals, and even CBD-infused Coffee. CBD products have gained immense popularity in health and wellness circles thanks to their natural support of our endocannabinoid system (ECS).
CBD was first discovered in 1940 by Roger Adams, a prominent organic chemist at the University of Illinois. Shortly thereafter, other scientists began testing isolated cannabinoids on lab animals; notably, Walter S. Loewe ran trials on mice and rabbits with the cannabinoids THC, CBD and CBN. He found that CBD produced no observable effects in the animals’ behavior while THC caused, what he called, a “central excitant action” in rabbits. Despite science’s movement forward, scientists were completely unaware of the cannabinoids’ chemical structure, so no one could tell which specific compound resulted in which effect.